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  1. What happens to my body during menopause? Menopause is a normal, natural event associated with reduced functioning of the ovaries due to aging, resulting in lower levels of estrogens and other hormones. Changes in these hormones cause symptoms of menopause, including hot flashes and bone loss. Menopause is usually confirmed when a woman has not had her menstrual period for 12 consecutive months.
  2. What are hot flashes? When estrogen levels begin dropping during menopause, some women get very uncomfortable symptoms, such as feelings of warmth in the face, neck, and chest, or sudden strong feelings of heat and sweating called hot flashes. In some women, the symptoms are mild, and they will not need to take medicines. In other women, symptoms can be more severe. Based on survey data, an estimated 50% of postmenopausal women experience moderate-to-severe hot flashes.
  3. What is the connection between bone loss and estrogen? Lower levels of estrogens at the time of menopause are associated with rapid bone loss and an increased risk of osteoporosis. Osteoporosis, the most common bone disease, becomes a serious health concern in postmenopausal women. Approximately 50% of women in the U.S. 50 years of age or older have low bone mass, putting them at risk for osteoporosis.
  4. What is DUAVEE™ (conjugated estrogens/bazedoxifene), and how is it different? DUAVEE is the first and only therapy to pair conjugated estrogens with an estrogen agonist/antagonist, also known as a selective estrogen receptor modulator (SERM).

    For over 60 years, estrogens have been used as hormonal treatments to help manage moderate-to-severe hot flashes and help prevent postmenopausal bone loss. But in the treatment of postmenopausal women with a uterus, the use of estrogens alone can increase the risk of developing cancer of the uterine lining. So estrogens have been traditionally paired with a progestin to decrease the risk of hyperplasia (the thickening of the endometrium), which can be a precursor to cancer. DUAVEE uses bazedoxifene, a SERM, in place of a progestin to help protect the uterine lining against hyperplasia that may result from taking estrogens alone.
  5. Who should not take DUAVEE? You should not take DUAVEE if you have or had blood clots; are allergic to any of its ingredients; have unusual vaginal bleeding; have or had certain cancers (e.g., uterine or breast), liver problems, or bleeding disorders; or are pregnant, may become pregnant, or are breastfeeding a baby.
  6. What should you talk to your doctor about before taking DUAVEE? DUAVEE may increase the chance of getting blood clots or strokes, so discuss this with your doctor if you’re going to have surgery or be on bed rest.

    Before taking DUAVEE, it is important that you share your complete health history with your doctor. Inform your doctor if you have any unusual vaginal bleeding, and/or have any other medical conditions. Tell your doctor about all the medicines you take, especially if you take other hormonal medicines, including progestins.
  7. What are the common side effects of DUAVEE? Some common side effects include muscle spasms, nausea, diarrhea, upset stomach, abdominal pain, throat pain, dizziness, and neck pain.
  8. How long do I take DUAVEE? DUAVEE should be taken for the shortest time possible and only for as long as treatment is needed. You and your doctor should talk regularly about whether you still need treatment with DUAVEE.

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