HOW DUAVEE WORKS

LET’S TALK MORE ABOUT
HOW THIS COMBINATION WORKS

Here’s some background on hormone therapies: Over the past 60 years, estrogens have been used to effectively manage hot flashes due to menopause. But for postmenopausal women who still have a uterus, taking estrogens alone increases the chance that the uterine lining will thicken (which can lead to cancer of the uterus). Adding a progestin can help lower this risk. That’s why most estrogens have traditionally been combined with a progestin.

DUAVEE is an estrogen therapy for postmenopausal women with a uterus that
uses bazedoxifene in place of a progestin,
making it the first and only pairing of its kind.

TO SUM IT UP, DUAVEE COMBINES:

CONJUGATED
ESTROGENS

(which help provide significant relief from
moderate-to-severe hot flashes
due to menopause and
prevent postmenopausal bone loss)

BAZEDOXIFENE

(an estrogen agonist/antagonist, also known
as a selective estrogen receptor modulator or
SERM, which helps protect the uterine lining
from the thickening that may occur in women
who take estrogens alone)

 

HOW DUAVEE WORKS

LET’S TALK MORE ABOUT
HOW THIS COMBINATION WORKS

Here’s some background on hormone therapies: Over the past 60 years, estrogens have been used to effectively manage hot flashes due to menopause. But for postmenopausal women who still have a uterus, taking estrogens alone increases the chance that the uterine lining will thicken (which can lead to cancer of the uterus). Adding a progestin can help lower this risk. That’s why most estrogens have traditionally been combined with a progestin.

 

Terms and Conditions apply. Savings up to $70 per prescription with the DUAVEE Savings Card. Card will be accepted only at participating pharmacies. This Card is not health insurance. No membership fees. Co-pay savings is up to $840 per patient per calendar year. For more information, call 1-866-881-2545 or contact Pfizer at PO Box 29387, Mission, KS 66201.

 

Are you feeling the heat? Learn about an Rx treatment that can help with moderate-to-severe hot flashes due to menopause: www.duavee.com >>

IMPORTANT SAFETY INFORMATION

IMPORTANT SAFETY INFORMATION & INDICATIONS

Do not take additional estrogens, progestins, or estrogen agonists/antagonists while taking DUAVEE® (conjugated estrogens/bazedoxifene).

Using estrogen may increase your chance of getting cancer of the uterus. Report any unusual vaginal bleeding right away while taking DUAVEE. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus. A healthcare provider should check unusual vaginal bleeding to find the cause.

Do not use estrogens to prevent heart disease, heart attacks, strokes, or dementia.

Estrogens may increase the chance of getting blood clots or strokes.

Using estrogens may increase the chance of getting dementia, based on a study of women 65 years of age or older.

You and your healthcare provider should talk regularly about whether you still need treatment with DUAVEE.

Do not use DUAVEE if you: have or had blood clots; are allergic to any of its ingredients; have unusual vaginal bleeding; have or had certain cancers (eg, uterine or breast), liver problems, or bleeding disorders; or are pregnant, may become pregnant, or are breastfeeding a baby.

The use of estrogen alone has been reported to result in an increase in abnormal mammograms requiring further evaluation. The effect of treatment with DUAVEE on the risk of breast and ovarian cancer is unknown.

Estrogens increase the risk of gallbladder disease. Discontinue estrogen if loss of vision, pancreatitis, or liver problems occur. If you take thyroid medication, consult your healthcare provider, as use of estrogens may change the amount needed.

The most common side effects include muscle spasms, nausea, diarrhea, upset stomach, abdominal pain, throat pain, dizziness, and neck pain.

 

INDICATIONS

DUAVEE is used after menopause for women with a uterus to reduce moderate-to-severe hot flashes and to help reduce the chances of developing osteoporosis.

If you use DUAVEE only to prevent osteoporosis due to menopause, talk with your healthcare provider about whether a different treatment or medicine without estrogens might be better for you. DUAVEE should be taken for the shortest time possible and only for as long as treatment is needed. You and your healthcare provider should talk regularly about whether you still need treatment with DUAVEE.

Please see Full Prescribing Information, including BOXED WARNING.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit http://www.fda.gov/medwatch or call 1-800-FDA-1088.

Back to Top