DUAVEE & BONE LOSS

stand up to
postmenopausal osteoporosis

Duavee is for postmenopausal women who have NOT had a hysterectomy (i.e., women with a uterus).

In studies of 1- and 2-years' duration, on average, Duavee significantly increased bone mineral density of the total hip and lumbar spine to help prevent postmenopausal osteoporosis.

While you're taking Duavee, it may help reduce the chances of developing postmenopausal osteoporosis, a serious bone disease caused by a decrease in bone mineral density, leading to thin, weak bones.

If you use Duavee only to prevent osteoporosis due to menopause, talk with your doctor about whether a different treatment or medicine without estrogens might be better for you.

Duavee bone mineral density increase was compared to placebo. Patients also took calcium and vitamin D daily.

 

Duavee was evaluated in 2 studies to determine the effects of bazedoxifene/conjugated estrogens combinations on the thickening of the lining of the uterus and the prevention of osteoporosis in postmenopausal women with a uterus. Study 1 compared the effects of Duavee vs placebo in 3397 postmenopausal women with a uterus between the ages of 40 and 75 years who were postmenopausal for more than 5 years or for 1-5 years with a risk factor for osteoporosis. The change in lumbar bone mineral density was measured at 2 years of treatment. Study 2 evaluated the prevention of osteoporosis in 590 women who were 1-5 years postmenopausal. Women also took calcium and vitamin D daily.

 

DUAVEE & BONE LOSS

stand up to postmenopausal osteoporosis

Duavee is for postmenopausal women who have NOT had a hysterectomy (i.e., women with a uterus).

In studies of 1- and 2-years' duration, on average, Duavee significantly increased bone mineral density of the total hip and lumbar spine to help prevent postmenopausal osteoporosis.

While you're taking Duavee, it may help reduce the chances of developing postmenopausal osteoporosis, a serious bone disease caused by a decrease in bone mineral density, leading to thin, weak bones.

If you use Duavee only to prevent osteoporosis due to menopause, talk with your doctor about whether a different treatment or medicine without estrogens might be better for you.

Duavee bone mineral density increase was compared to placebo. Patients also took calcium and vitamin D daily.

Duavee was evaluated in 2 studies to determine the effects of bazedoxifene/conjugated estrogens combinations on the thickening of the lining of the uterus and the prevention of osteoporosis in postmenopausal women with a uterus. Study 1 compared the effects of Duavee vs placebo in 3397 postmenopausal women with a uterus between the ages of 40 and 75 years who were postmenopausal for more than 5 years or for 1-5 years with a risk factor for osteoporosis. The change in lumbar bone mineral density was measured at 2 years of treatment. Study 2 evaluated the prevention of osteoporosis in 590 women who were 1-5 years postmenopausal. Women also took calcium and vitamin D daily.

 

*Eligibility required. No membership fees. The Card is not health insurance. The Card will be accepted only at participating pharmacies. Individual savings limited to $70 per monthly prescription or $840 in maximum total savings per calendar year. If you are enrolled in a state or federally funded prescription insurance program, you may not use the savings card even if you elect to be processed as an uninsured (cash-paying) patient. For any questions, please call 1-866-881-2545, or write Pfizer, Attn: Duavee, 66 Hudson Boulevard East, New York, NY 10001-2192. Terms and Conditions apply. Expires 12/31/2024. Visit www.Duavee.com for full Terms and Conditions. Pfizer reserves the right to rescind, revoke or amend this offer without notice.

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IMPORTANT SAFETY INFORMATION

IMPORTANT SAFETY INFORMATION AND INDICATIONS

Do not take progestins, additional estrogens, or additional estrogen agonists/antagonists while taking Duavee® (conjugated estrogens/bazedoxifene).

Using estrogen alone may increase your chance of getting cancer of the uterus. Report any unusual vaginal bleeding right away while taking Duavee. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus. A healthcare provider should check unusual vaginal bleeding to find the cause.

Do not use estrogens to prevent heart disease, heart attacks, strokes, or dementia.

Estrogen alone may increase the chance of getting blood clots or strokes.

Using estrogen alone may increase the chance of getting dementia, based on a study of women 65 years of age or older.

The risks listed above are based on a study of an estrogen-alone oral product. Since other products and doses have not been studied in the same way, it is not known how the use of Duavee will affect your chances of getting these conditions.

Estrogens should be used at the lowest dose possible, only for as long as needed. You and your healthcare provider should talk regularly about whether you still need treatment with Duavee.

Do not use Duavee if you: have or had blood clots; are allergic to estrogens or bazedoxifene, the active ingredients of Duavee; have unusual vaginal bleeding; have or had certain cancers (e.g., uterine or breast), liver problems, or bleeding disorders; or are pregnant.

If you take thyroid medication, consult your healthcare provider, as use of estrogens may change the amount needed.

Serious side effects include blood clots, stroke, heart attack, cancer of the lining of the uterus, breast cancer, cancer of the ovary, dementia, gallbladder problems, loss of vision, high blood pressure, increased fats in your blood, liver problems, thyroid problems, fluid retention, low calcium, swelling of your mouth or tongue, worsening of other medical problems such as asthma, diabetes, epilepsy, migraines, a genetic problem called porphyria, lupus and liver problems.

Call your healthcare provider right away if you have any of the following warning signs, or any other unusual symptoms that concern you: new breast lumps, unusual vaginal bleeding, changes in vision or speech, sudden new severe headaches, severe pains in your chest or legs with or without shortness of breath, weakness and fatigue.

Less serious, but common side effects include: muscle spasms, nausea, diarrhea, upset stomach, abdominal pain, throat pain, dizziness, neck pain.

 

INDICATIONS

Duavee is used after menopause for women with a uterus to reduce moderate to severe hot flashes and to help reduce the chances of developing osteoporosis (thin, weak bones).

If you use Duavee only to prevent osteoporosis due to menopause, talk with your healthcare provider about whether a different treatment or medicine without estrogens might be better for you.

Duavee should be taken for the shortest time possible and only for as long as treatment is needed. You and your healthcare provider should talk regularly about whether you still need treatment with Duavee.

Please see full Prescribing Information, including BOXED WARNING and Patient Information.

Patients should always ask their doctors for medical advice about adverse events.

You are encouraged to report adverse events related to Pfizer products by calling 1-800-438-1985 (U.S. only). If you prefer, you may contact the U.S. Food and Drug Administration (FDA) directly. Visit http://www.fda.gov/MedWatch or call 1-800-FDA-1088.

This site is intended only for U.S. residents. The products discussed in this site may have different product labeling in different countries. The information provided is for educational purposes only and is not intended to replace discussions with a healthcare provider.

Doctors may recommend alternative treatment options to their patients.

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